Glutamine is non-essential and conditionally essential amino acid in humans.
It means that the body can usually synthesize sufficient amounts of it.
But in some cases of stress, the body's demand for glutamine increases, and then glutamine must be obtained from the diet.
Glutamine release in our body is mainly controlled by key metabolic organs, such as the gut, liver, and skeletal muscles.
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Glutamine, Abundant And Versatile
Glutamine is one of the most abundant and versatile amino acids in the body. (source ◳)
Glutamine serves as a building block in the biosynthesis of most proteins. (source ◳)
You can find benefits of glutamine in Glutamine: 2 Research-Backed Benefits
Glutamine Can Become Essential
Even though glutamine is classified as nonessential, there are circumstances where glutamine can become essential. It is during catabolic/hypercatabolic situations for metabolic function. (source ◳)
Hypercatabolism means an excessive metabolic breakdown of complex substances, like protein, within the body. (source ◳)
This condition can occur, for example, in muscle loss and impaired cellular energy in chronic diseases, such as diabetes mellitus or chronic heart failure (CHF). (source ◳)
During catabolic/hypercatabolic circumstances, the demand for glutamine increases dramatically. It may lead to glutamine deprivation and severe impairment of the immune function. (source ◳)